Peter Griffin: Peter is the head of the Griffin household and the central character in the show. He is married to Lois, and is the father of Meg, Chris, and Stewie. His voice is performed by the show's creator and lead writer, Seth MacFarlane. Peter is unintelligent and consistently depicted as crude and lowbrow. He enjoys activities such as going to up-market tailors and farting inside the suits. His favorite pastime is watching TV.

Lois Griffin: She is the wife of Peter Griffin, and the mother of Meg, Chris, and Stewie. She is voiced by Alex Borstein.